Polypill reduces BP and LDL in healthy patients

On its website, ABC News reports that “researchers at the Wolfson Institute of Preventive Medicine in London tested a polypill consisting of three blood pressure medications – amlodipine, losartan, and hydrochlorothiazide – along with simvastatin, a cholesterol-busting drug,” and “found that during a three-month period, a single polypill significantly lowered blood pressure and cholesterol levels in 84 study participants who were age 50 and older and had no history of cardiovascular disease.”

Reuters reports that the research was published in the PLoS One.

MedPage Today reports, “Through 12 weeks of treatment, the reductions were 17.9 mm Hg (95% CI 15.7 to 20.1) for systolic blood pressure, 9.8 mm Hg (95% CI 8.1 to 11.5) for diastolic pressure, and 54 mg/dL (95% CI 46 to 62) for LDL cholesterol.”

While “the study was too short to assess the impact on cardiovascular events, sustained reductions at those levels would be expected to reduce rates of ischemic heart disease events and stroke by a relative 72% and 64%, respectively, the researchers reported.”

The study used “amlodipine 2.5 mg, losartan 25 mg, hydrochlorothiazide 12.5 mg and simvastatin 40 mg).

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