My Patients Ask — What supplements do you recommend I take before getting the COVID vaccine?

The short answer: none. A longer answer and explanation is below.

This question likely originates in the myriad internet and social media posts saying that having the healthiest immune system possible before getting vaccinated is crucial in getting the best response.


However, what is likely NOT true are ads or posts claiming that taking the right mix of vitamins and minerals can help strengthen your immune system.

Prompted by the COVID pandemic, one Boston-based company is marketing the product Vacci-Prep, which is a mix of vitamins C, A, and D3, along with zinc, selenium, amino acids, and probiotics.

According to WebMD, Martin Floreani, president and CEO of Dentovations, the company making the new drug combination, says, “We recommend starting it 7 days before the vaccine and 7 days after,”

The product is expected to be available online in mid-February.

However, the company acknowledges that NO research exists to verify it can increase the immune response to the COVID vaccines. Nevertheless, he claims the list of vitamins and minerals was chosen based on other research suggesting the supplements helped immune response with other vaccinations.

For instance, he cites a study finding that having a healthy level of vitamin D was linked with a better response to the flu vaccine in a small study of prostate cancer patients.

Another study found that giving children vitamins A and D when they were low in those vitamins improved responses to the flu vaccine.

Blanka Kaplan, MD, a specialist in adult and pediatric allergy and immunology at Northwell Health in Great Neck, NY. is skeptical, and tells WebMD, “There is no scientific data that shows that taking any vitamins, minerals, or probiotics prior to the vaccination will prevent an allergic reaction or will improve the immune response to the vaccine.”

She does recommend getting enough sleep, staying physically active and well-hydrated, along with eating well to give your immune system the best chance to “do its job.”

I would agree. See my recent blog: My Patients Ask — Some say behavior changes give a better COVID vaccine response.

© Copyright WLL, INC. 2021. This blog provides a wide variety of general health information only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment from your regular physician. If you are concerned about your health, take what you learn from this blog and meet with your personal doctor to discuss your concerns.

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2 Responses to My Patients Ask — What supplements do you recommend I take before getting the COVID vaccine?

  1. Jennifer Haskell says:

    How do you respond to Dr. Sherri Tenpenny’s claims about instances of hyper-immune responses and her claims that millions may die from the vaccine but it will be blamed on a new strain of COVID to make an argument for even MORE deadly vaccines.? See 2/19/21??? I am scheduled to get the vaccine next week and my husband and his sister and many other family members have gotten the vaccine with no bad response, but i have other family members pushing me to NOT get it because of claims like this.????

  2. As I have said before, time will tell if her theory is credible. But, here’s the most recent report about ADE (antibody-dependent enhancement) and the COVID vaccines of which I’m aware ( which concludes that there has been “no sign of ADE during the preclinical animal studies. No sign during the human clinical trials. No sign during the initial vaccine rollouts into the population. And (so far) no sign of ADE even with the variant strains in different parts of the world. We have things to worry about in this pandemic, but as far as I can tell today, antibody-dependent enhancement does not seem to be one of them. I understand why people would worry about it, and want to avoid it. But if you’re coming across reports that say that it’s a real problem right now and that you should avoid getting vaccinated because of it, well, I just don’t see it. Some of that is well-intentioned caution, and some of it is probably flat-out anti-vaccine scaremongering.”

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