Tag Archives: menopausal symptoms

Soy tablets NOT effective treating menopausal symptoms

Taking soy supplements will NOT ease the symptoms of menopause or protect against bone loss in women, researchers have reported. In fact, among women in the first five years of menopause, taking soy supplements was associated with a higher risk of bone loss compared with placebo, but significantly more women taking soy supplements had hot flashes. Continue reading

ConsumerLab.com announces test results of supplements for menopause

Women looking for relief from hot flashes and other menopausal symptoms often turn to supplements containing estrogen-like isoflavones (from soy or red clover), the herbal remedy black cohosh, or creams containing progesterone. A new report from ConsumerLab.com provides quality ratings for over 20 such products and identifies those providing amounts of compounds shown to be effective in clinical studies.  Continue reading

Flaxseed does not help reduce hot flashes

A new study is showing that flaxseed is NOT associated with a significant reduction in hot flashes for women with menopausal symptoms or breast cancer survivors taking anti-estrogen drugs. Continue reading

St. John’s wort may cool the hot flashes of menopause

Reuters Health has a nice report on the popular herbal remedy, St. John’s wort, and some news from a small study that says it may help ease menopausal hot flashes. St. John’s wort is probably best known as an herbal antidepressant, with some clinical trials suggesting that it can help relieve mild to moderate depression symptoms. A few studies have also investigated the herb’s effects on menopausal symptoms, but have focused on its impact on mood — and not the so-called vasomotor symptoms of menopause, which include hot flashes and night sweats. Here’s the Reuter’s report:

“(The) findings of our study suggest that this herbal medicine can be used to treat hot flashes due to menopause, and it is a new finding about the usage of St. John’s wort,” Marjan Khajehei, of Shiraz University of Medical Sciences in Iran, told Reuters Health in an email.

Khajehei and her colleagues found that among a group of women they randomly assigned to take either St. John’s wort or an inactive placebo for eight weeks, those using the herb saw a greater reduction in daily hot flashes.

Among women taking St. John’s wort, the average number of hot flashes declined from roughly four per day at the start of the study to fewer than two per day at week eight. In contrast, women in the placebo group were having an average of 2.6 hot flashes per day by the eighth week. The herb also appeared to lessen the duration and severity of the women’s hot flashes, Khajehei and her colleagues report in the journal Menopause.

The study included 100 women who were 50 years old, on average, and had been having moderate to severe hot flashes at least once per day. The women were randomly assigned to take either drops containing St. John’s wort extract or placebo drops three times a day for eight weeks. While women in both groups saw their hot flashes improve, those taking the herbal extract had a better response, on average.

St. John’s wort contains estrogen-like plant compounds called phytoestrogens, and it’s possible that these compounds explain the benefits seen in this study, according to Khajehei. However, she said, further research is needed to confirm that the herb eases hot flashes and that phytoestrogens are the reason.

St. John’s wort is generally considered safe when taken as directed, Khajehei noted. Still, she added, since phytoestrogens have mild estrogen-like effects in the body, women who have any contraindications to using estrogen — such as a history of breast or endometrial cancers — should talk with their doctors before starting St. John’s wort.

The herb has also been shown to interact with certain medications, including antidepressants, the heart medication digoxin, the birth control pill, and the blood thinner warfarin.

I join with many other experts who generally recommend that people on any medication talk with their doctors or pharmacists before starting an herbal remedy.

The study is published in the journal Menopause, March 2010. You can find the table of contents of this edition here. The abstract of the study is available for free toward the bottom of the page.

To learn more about alternative medicine, take a look at my best-selling book, Alternative Medicine: The Christian Handbook. You can also view the table of contents here and read the first chapter here.

You can read more on this topic at my blog entry, Natural Medications (Herbs, Vitamins, and Supplements) for Menopausal Symptomshere.

Amberen a new supplement for hot flashes. Does it work?

According to a new report by the Natural Medicines Comprehensive Database (NMCD), Amberen is a popular new dietary supplement used mainly for menopausal symptoms such as hot flashes. The manufacturer says the product is “Backed by published clinical, toxicology and safety studies, and over 30 years of research, Amberen is your best choice for a natural alternative to HRT.”

The NMCD say, of Amberen, “It contains unusual ingredients including ammonium succinate, calcium disuccinate, magnesium disuccinate hydrate, and others.” But, does it work? The Database relates, “Although patient testimonials suggest that the product might help, there is NO reliable clinical research.”

To doctors NMCD says, “Don’t recommend this product until there is reliable evidence of safety and effectiveness.” For menopausal women, this is one product I’d recommend you skip until there’s more reliable data.

You can read more on this topic at my blog entry, Natural Medications (Herbs, Vitamins, and Supplements) for Menopausal Symptoms, here.

No Science to Back Actress Somers’ Potentially Harmful Menopause Advice

Miserable in menopause, Elizabeth Alsgaard pondered an awful choice: Drenching hot flashes or hormone therapies that might raise the risk of cancer. What former actress Suzanne Somers raved about held much more appeal — custom-mixed “bioidentical” hormones, just like ones the body makes.
“Anything I can put into my body that’s natural has to be better,” said Alsgaard, a California audiologist who admitted having “no knowledge base to go on other than fear” when she took Somers’ advice.
Millions of women have tried custom-compounded hormones or herbal supplements like black cohosh and red clover since 2002, when a big federal study found risks from traditional hormone replacement therapy, or HRT.
Alternative remedies are especially popular with upscale, educated women who like to research and find their own solutions to medical problems. They like the idea of personalized treatments versus off-the-shelf prescription drugs.
However, instead of a safer option, they are getting products of unknown risk that still contain the estrogen many of them fear, women’s health experts say.
“Misinformation is rampant” about bioidenticals, said Dr. JoAnn Manson, preventive medicine chief at Harvard-affiliated Brigham and Women’s Hospital in Boston. “It really is buyer beware.”
She and other experts explain:
—”Bioidentical” is a marketing term that has no accepted medical meaning. Its implied benefit is not unique to alternative remedies; many prescription drugs contain hormones that chemically match estrogens and progesterones made naturally by the body.
—Custom-compounded hormones are not approved by the federal Food and Drug Administration and have not been proved safe or effective. They may carry the same cancer and heart risks as traditional treatments and have had even less testing to find out.
—Hormone preparations do not need to be customized for each woman; a few standard doses work for almost everyone, medical experts say. The saliva tests that some women are given to tailor formulas are of dubious value because hormone levels fluctuate widely throughout the day.
—Compounding pharmacists use such different methods that a customized prescription can contain widely varying amounts of hormones depending on who fills it.
—Many compounders use estriol, a form of estrogen not approved for sale in the United States. The FDA is in a battle with compounding pharmacies over its use.
The bottom line?
“Women need to understand there’s no rigorous evidence these preparations are any more effective or any safer than traditional hormone therapy. In fact, there’s much less evidence for efficacy and very little research on long-term safety,” said Manson, who has no industry ties and was a key researcher in the big federal study that warned women in 2002 of the health risks from long-term hormone use.
For years, medical groups have warned against custom-compounded hormones. The American College of Obstetricians and Gynecologists has denounced claims about their safety. The American Medical Association has urged more FDA oversight. The Federal Trade Commission has filed complaints against online sellers who made health claims for natural progesterone creams without supporting evidence.
In 2001, the government tested 29 products from compounding pharmacies and found that one-third did not meet standard quality benchmarks, including potency problems, Manson writes in her book, “Hot Flashes, Hormones and Your Health.”
That has not stopped their popularity, and Somers has promoted them in several best-selling books and on “The Oprah Winfrey Show” earlier this year.
“I laugh when they call me a quack,” said Somers, who rubs hormones on her arms, injects them vaginally and takes some 60 supplement pills each day. In a phone interview, Somers said she is not trying to play doctor but to share with women what worked for her.
The issue flared last year, when the FDA declared that custom-mixed hormones were no safer than traditional treatments and warned pharmacies to stop using estriol, which is not approved in the United States for any use. (Most traditional menopause therapies use a different form of estrogen with a similar name — estradiol.)
The industry claimed it was being persecuted and fought back. In full-page ads in major newspapers, several alternative medicine groups claimed that estriol is safe, criticized “synthetic, hyper-expensive” prescription drugs, and asked, “Why is the FDA so hostile to ‘natural’ medicine?”
There are several thousand compounding pharmacies in the United States and hormones are a significant part of their business, said L.D. King, executive director of the International Academy of Compounding Pharmacists in Missouri City, Texas. No one knows how many women use these products, but “we believe the FDA action on the estriol issue would have affected hundreds of thousands of women,” King said.
A group of nine compounding pharmacies sued the FDA. After a murky ruling by a federal court in Louisiana centering on federal versus states’ authority, neither side appealed, King said.
“It gets complicated and there’s not a win,” he said. “We continue to advocate that FDA’s action is wrong.”
Alsgaard was not aware of the flap. She was 52 and living in San Diego when she stopped taking birth control pills, and menopause symptoms “hit me like a brick wall.” Her doctor, a specialist in women’s health, urged traditional hormone replacement therapy.
“She was just so aggressive it really flipped me out,” said Alsgaard, who feared a cancer risk from the pills. After reading one of Somers’ books, Alsgaard went to a different doctor specializing in bioidentical hormones.
“She spoke at a physician’s level, talked about metabolic things I didn’t understand and sold me a couple hundred dollars of supplements I never took,” Alsgaard said. “I was so desperate it was like, ‘OK, OK, just give me whatever I need.”‘
Although Alsgaard did not use the supplements, she did spend about $1,000 for saliva tests, hormone creams and custom-compounded hormone pills the doctor prescribed. Six months later, she was still miserable.
Disgusted with the doctor and in the middle of moving to Los Angeles, she found a new doctor and asked again for a natural remedy, believing those are safer than traditional hormone pills.
“He did a lot more extensive workup on me and put me on a bioidentical implant, a pellet implanted into the hip,” she said.
Pellets containing estrogen, testosterone or both are the latest craze in this field. They are implanted just under the skin every few months under a local anesthetic, and are not FDA-approved for treating menopause. Problems that have been reported include difficulty removing the pellets if the therapy has to be discontinued, infection or pain at the injection site and fluctuating blood levels of estrogen, including a potentially high cumulative effect over several years.
Alsgaard did not know the pellets lack FDA approval. Her first, implanted in April, has done the trick, she said.
“I feel awesome. I have no night sweats, no hot flashes, no mood swings. After feeling so terrible, I’d forgotten how good it feels to feel normal,” she said.
Whether her estrogen pellet is any safer than traditional estrogen pills is unknown.
Her physician, Dr. Kevin Pimstone, an internist at UCLA, said hormone pellets are “a very small part of my practice” — a few patients a month.
“I’m a really conventional doctor who offers this to patients who ask for it,” he said. “I don’t think there’s any evidence that bioidentical hormones are any safer than conventional hormones.”
On the Net:
FDA on hormone compounds: http://tinyurl.com/kv7sqb
Federal alternative medicine center: http://nccam.nih.gov/health/menopause/menopausesymptoms.htm
The AP is carrying a story about a woman who was miserable in menopause, Elizabeth Alsgaard, who “pondered an awful choice:” Drenching hot flashes or hormone therapies that might raise the risk of cancer. What former actress Suzanne Somers raved about held much more appeal — custom-mixed “bioidentical” hormones, just like ones the body makes. But, is there any science to support Somers’ claims? And, could her claims be potentially harmful to women? Continue reading

Hormones beat botanicals for hot flashes but memory may suffer

My patients suffering with perimenopausal or menopausal symptoms often wonder about the safety and effectiveness of hormone therapy or botanicals (such as black cohosh and red clover) to treat their symptoms. Two recent studies will help inform wise decision making for these problems.

More Information: Continue reading