Daily Archives: May 25, 2010

Overall survival rate for children with cancer approximately 80%

The Wall Street Journal “Health Blog” reported that research published online in the Journal of Clinical Oncology indicates that the overall survival rate for children with cancer is now approximately 80%. This is GREAT news.

However, during the past 10-20 years, the five-year survival rates for most solid tumors in children and teenagers have not changed, but overall, we’re curing more childhood cancer than we ever have in the past.

Nevertheless, with many newer and more effective treatments available for kids, the researchers report that “when 1975 age-specific death rates for children are used as a baseline, approximately 38,000 childhood malignant cancer deaths were averted in the United States from 1975 through 2006 as a result of more effective treatments identified and applied during this period.”

The blog also included an interview with Eugenie Kleinerman, professor and head of pediatrics at M.D. Anderson Cancer Center.

Calcium and multivitamins may be linked to reduced breast cancer risk

Daily Calcium Plus Vitamin D Supplements May Reduce Fracture RiskBloomberg News reports that “calcium doesn’t just build strong bones, it may fight cancer too,” according to a study presented at the meeting of the American Association for Cancer Research.

Investigators found “that women who took calcium had a 40% lower risk of getting breast cancer, while those getting multivitamins showed a 30% reduction in risk.”

These “data contradict results of a December 2008 trial that showed no reduction in cancer risk from vitamin supplements.”

HealthDay pointed out that “the authors of the study … did not separate out which specific vitamins might be beneficial, but suggested that the interactions of different vitamins together might account for the beneficial effect.”

You can read a couple of my other posts about the benefits of calcium:

A couple of other tips about calcium. I recommend synthetic calcium carbonate. No reason to take a natural calcium (coral, oyster shell, dolamite earth, or bone) as they may be contaminated with heavy metals.

Also, the body absorbs calcium best when it’s taken with food. But, remember, taking more than 600 mg of elemental calcium in a single dose is not recommended. If you’re going to take more than 600 mg, take it in two or more doses.

Last, but not least, if you are on any prescription medications, check with your pharmacist or physician about whether the can or should not be taken with vitamins or supplements.

Hormone Therapy for Menopause Reviewed

According to a new review of the role of perimenopausal hormone therapy published in Obstetrics & Gynecology, women must be informed of the potential benefits and risks of all treatment options for menopausal symptoms and concerns and should receive individualized care. Here’s an update from MedPage. It’s long, but very helpful:

“With the first publication of the results of the Women’s Health Initiative (WHI) trial in 2002, the use of HT [hormone therapy] declined dramatically,” write Jan L. Shifren, MD, and Isaac Schiff, MD, from Harvard Medical School and Massachusetts General Hospital in Boston.

“Major health concerns of menopausal women include vasomotor symptoms, urogenital atrophy, osteoporosis, cardiovascular disease, cancer, cognition, and mood. … Given recent findings, specifically regarding the effect of the timing of HT initiation on coronary heart disease [CHD] risk, it seems appropriate to reassess the clinician’s approach to menopause in the wake of the recent reanalysis of the WHI.”

Many therapeutic options are currently available for management of quality of life and health concerns in menopausal women.

Treatment of vasomotor hot flushes and associated symptoms is the main indication for hormone therapy, which is still the most effective treatment of these symptoms and is currently the only US Food and Drug Administration–approved option.

For healthy women with troublesome vasomotor symptoms who begin hormone therapy at the time of menopause, the benefits of hormone therapy generally outweigh the risks.

However, hormone therapy is associated with a heightened risk for coronary heart disease. But, based on recent analyses, this higher risk is attributable primarily to older women and to those who reached menopause several years previously.

Hormone therapy should not be used to prevent heart disease, based on these analyses. However, this evidence does offer reassurance that hormone therapy can be used safely in otherwise healthy women at the menopausal transition to manage hot flushes and night sweats.

Although hormone therapy may help prevent and treat osteoporosis, it is seldom used solely for this indication alone, particularly if other effective options are well tolerated.

Short-term treatment with hormone therapy is preferred to long-term treatment, in part because of the increased risk for breast cancer associated with extended use. Also, the lowest effective estrogen dose should be given for the shortest duration required because risks for hormone therapy increase with advancing age, time since menopause, and duration of use.

Low-dose, local estrogen therapy is recommended vs systemic hormone therapy when only vaginal symptoms are present.

Alternatives to hormone therapy should be recommended for women with or at increased risk for disorders that are contraindications to hormone therapy use. These include breast or endometrial cancer, cardiovascular disease, thromboembolic disorders, and active hepatic or gallbladder disease.

In addition to estrogen therapy, progestin alone, and combination estrogen-progestin therapy, there are several nonhormonal options for the treatment of vasomotor symptoms:

  • Lifestyle interventions include reducing body temperature,
  • maintaining a healthy weight,
  • stopping smoking,
  • practicing relaxation response techniques, and
  • receiving acupuncture.

Although efficacy greater than placebo is unproven, nonprescription medications that are sometimes used for treatment of vasomotor symptoms include isoflavone supplements, soy products, black cohosh, and vitamin E. (You can read more about these in a previous post of mine.)

There are several nonhormonal prescription medications sometimes used off-label for treatment of vasomotor symptoms, but they are not approved by the Food and Drug Administration for this purpose. These drugs, and their accompanying potential adverse effects, include the following:

  • Clonidine, 0.1-mg weekly transdermal patch, with potential adverse effects including dry mouth, insomnia, and drowsiness.
  • Paroxetine (10 – 20 mg/day, controlled release 12.5 – 25 mg/day), which may cause headache, nausea, insomnia, drowsiness, or sexual dysfunction.
  • Venlafaxine (extended release 37.5 – 75 mg/day), which is associated with dry mouth, nausea, constipation, and sleeplessness.
  • Gabapentin (300 mg/day to 300 mg 3 times daily), with possible adverse effects of somnolence, fatigue, dizziness, rash, palpitations, and peripheral edema.

“Women must be informed of the potential benefits and risks of all therapeutic options, and care should be individualized, based on a woman’s medical history, needs, and preferences,” the review authors write.

“For women experiencing an early menopause, especially before the age of 45 years, the benefits of using HT until the average age of natural menopause likely will significantly outweigh risks.